Joined: 13 Dec 2006
Location: Cleveland, OH
|Posted: Dec Sat 16, 2006 9:29 pm Post subject: Bladder - Disease Linked to Adrenals?
|Bladder - Disease Linked to Adrenals?
Reported November 17, 2003 Cause of Chronic Bladder Disease Studied (Ivanhoe Newswire) -- Interstitial cystitis (IC) is a chronic and incurable inflammatory bladder disease that affects about 700,000 women in the United States. The cause of IC is unknown and doctors generally just treat the symptoms of the disease. But new research done in house cats shows the cause of IC may lie within the adrenal glands.
Symptoms of IC in humans include chronic pelvic pain, inflammation of the bladder and increased urination frequency and urgency. Cats with the disease also have noticeable urinary problems. IC affects cats and humans in a similar manner, so urologists feel studying felines is one of the best ways to understand IC. Researchers from Ohio State University compared cats with IC to healthy cats to determine some differences.
Researchers looked at the adrenal glands of house cats with feline IC. The adrenal glands sit on top of the kidneys and are responsible for a number of bodily functions including hormone production and regulation of heart rate and blood pressure. Researchers found the adrenal glands of cats with IC were nearly half the size of those in the healthy cats.
Study authors then evaluated how the cats responded to an injection of a stress-inducing compound. Researchers measured the cortisol levels in the blood before and after the injection. They report, when compared to healthy cats, the adrenal glands of the diseased cats produced lower levels of the stress hormone cortisol after the injection. This suggests that the adrenal glands in the cat with IC may not provide adequate hormonal response during stressful situations.
Investigators conclude that, if they find similar adrenal gland abnormalities in humans with IC, they might be able to develop more effective treatments for the disease.
This article was reported by Ivanhoe.com, who offers Medical Alerts by e-mail every day of the week. To subscribe, go to: http://www.ivanhoe.com/newsalert/.