Joined: 13 Dec 2006
Location: Cleveland, OH
|Posted: Dec Thu 14, 2006 7:37 pm Post subject: Pycnogenol Thwarts Liver Damage (Tylenol)
|Pycnogenol Thwarts Liver Damage (Tylenol)
Acetaminophen-Induced Liver Damage May Be Thwarted By Grape Seed Extract
Brooklyn, NY -- April 13, 1998 -- Acetaminophen, the well-known and reliable over-the-counter analgesic, can cause serious damage to liver cells and tissues when an overdose is taken or it is used in combination with alcohol. In 1996 alone, 74,000 cases of cetaminophen toxicity were reported in the United States, according to United States Poison Control Centers figures.
A possible antidote to toxic doses of acetaminophen has been discovered by a professor at Long Island University's Brooklyn Campus. Sidhartha D. Ray of the University's Arnold & Marie Schwartz College of Pharmacy and Health Sciences has found that a novel grape seed extract (proanthycyanidin), known to have strong antioxidant properties, protects against acetaminophen-caused liver damage.
Working with colleagues at Creighton University, Ray pre-exposed male mice to non-toxic doses of the grape seed extract, followed either three or seven days later by acetaminophen at dose levels known to be toxic to the liver. Using several different blood, tissue and DNA measures, the seven-day pre-exposure to the grape seed extract appeared to afford what Ray describes as "dramatic protection" against liver damage caused by the toxic doses of acetaminophen.
Ray, who will present his results on April 21 at the Experimental Biology 98 meetings in San Francisco, conducted previous research to help define how acetaminophen causes cell death in the liver by affecting the DNA of the cells, contributing both to apoptosis (programmed cell death that occurs during cell renewal and the aging process) and necrosis (accidental or unprogrammed death of cells in response to physical injury or exposure to toxic substances.
"The results of this study show that the novel grape seed proanthycyanidin extract is a natural chemoprotectant and may be useful in defending cells against various environmental toxins," Ray explained.
An active researcher in the study of apoptosis, Ray is an active member of the Society of Toxicology, Research Society on Alcoholism and the Internal Society of Biomedical Research on Alcoholism. His laboratory received the prestigious American Academy of Clinical Toxicology Research Award (1995-96).
- - - - - - - - - - - - - - - -
Pycnogenols - A Powerful Antioxidant
Pycnogenol -- A Powerful Antioxidant, by Karen Baker (AltM Karen)
Pycnogenol* is a potent antioxidant that protects the body against free radicals. It is a natural plant extract made from the bark of the Maritime pine tree, which is found on the sandy coast of France. It contains a composite of approximately 40 natural ingredients, including proanthocyanidins, organic acids, and other biologically active components.
How does it work?
Oxidants inside your body can break down your cells and tissues when left unchecked. Pycnogenol, which is an antioxidant, is a free-radical fighter that has been found in laboratory studies to be even more powerful than Vitamins E or C and works hand-in-hand with many essential nutrients.
What does it do?
Studies show that Pycnogenol can protect against the effects of early aging. It has been found to strengthen capillaries, veins, and arteries; improve circulation and skin smoothness; fight inflammation; and improve joint flexibility. Pycnogenol also readily binds to collegen fibers, which improves the elasticity and integrity of connective tissues. Doctors have been telling us for years that it is possible to prevent many diseases with a diet rich in fruits and vegetables. This is because fruits and vegetables contain flavonoids, which are polyphenolic antioxidants, and are found in a concentrated form in this supplement.
What is the suggested dosage?
The suggested dosage is 1.5 - 3.0 mg per kilogram of body weight (2.2 lbs = 1 Kg) per day for 7 to 10 days, followed by a maintenance dose of 50 to 100 mg per day.
Is it safe?
Pycnogenol has been tested and researched for the last 30 years in France, the United Kingdom, Italy, Finland, Germany, Hungary, Japan, Switzerland, and the United States. The chemical structure, effects, and absence of toxicity have been confirmed through this research.
© 1998 Karen Baker
What is Pycnogenol? by Dr. Richard "Medicine Bear" Cantrell (AltM Echo)
Excerpt of article:
Pycnogenol does have excellent results in those who suffer from chronic diseases of connective tissue as well as allergies, arthritis, cardiovascular problems, and lupus. It is quite expensive, however, and I personally have found that even though there is a slight difference in the chemical makeup of Pycnogenol and that of grape seed, grape seed seems to produce results that are just as good for these type of ailments at a much lower price.
Taking supplements without removing harmful factors from the diet -- such as foods processed with chemicals, yeast, white bread and white flour, caffeine, alcohol, and tobacco -- renders little effect, since these substances seem to destroy the benefit of the supplements. It is important for those who are seeking an alternative to conventional medical treatment to realize that it is lifestyle changes that promote health, not numerous supplements added to a diet that is nutritionally deficient.
© 1998 Richard Cantrell
- - - - - - - - - - - - - - - -
by Charles Nohava (AltM Qi)
Pycnogenol is a remarkable herbal extract with a unique primary ingredient known as proanthocyanidin. It is a member of the flavonoid family, which is found in many plants as well as red wine. Commercially available sources of proanthocyanidolic oligomers (pycnogenol) -- or PCO for short -- include extracts from grape seeds and the bark of the Maritime (Landes) pine. Studies show that the grape seed extracts are substantially more potent and effective than the extract of pine bark. It is far more economical to extract PCO from grape seeds than it is from pine bark. As a result, the grape seed extract provides greater value at a lower price.
Pycnogenol now joins the brigade of other naturally derived antioxidants, such as Vitamin C, Vitamin E, selenium, and beta carotene. In vitro testing shows Pycnogenol to be 50 times more powerful than Vitamin E and 20 times more powerful than Vitamin C as an antioxidant. Dr. Jack Masquelier of the University of Bordeaux in France, the researcher who first developed the pine bark extraction process, has been awarded a US patent for the use of these naturally derived proanthocyanidins as free radical scavengers. Although Pycnogenol is relatively expensive, it is the most powerful, natural free-radical scavenger yet discovered.
Benefits: Benefits include prevention or minimization of the seriousness of sports injuries and prevention of diabetic retinopathy. It is also useful for patients with capillary fragility and for anyone needing maximum antioxidant function in their body, such as patients with a great tendency for atherosclerotic plaque formation. It is very helpful for collagen disorders.
Pycnogenol greatly enhances the effectiveness of vitamin C, so it is often sold in a combination capsule of vitamin C and Pycnogenol called PYC-C. It is scientifically proven to be nontoxic and highly bioavailable and continues to be effective after long-term usage. It is extremely stable, showing no loss of potency after 12 years of storage.
© 1998 Charles Nohava