Nature's Sunshine Products NSP

[CombinedNSP]

Paw Paw - Consequences of Cellular Damage

The Consequences of Cellular Damage, and Paw Paw Dr. William J. Keller, Vice Pres. of Health Sciences & Educational Services, NSP

Dr. Keller has been active in research, teaching, and service since 1972, and is a member of the American Society of Pharmacognosy (ASP), the American Association of Colleges of Pharmacy (AACP), and the American Association of Pharmaceutical Scientists (AAPS). His primary research interest revolves around the isolation, characterization, and biosynthesis of pharmacologically active compounds from higher plants. Another focuses on herbal medicines and their formulations, and researching potentially dangerous herb/drug, herb/food, and herb/herb interactions. Dr. Keller has delivered over 90 scientific addresses and has published over 60 research papers in refereed scientific journals, and has been awarded 22 research grants from federal, state, and private funding agencies. He was appointed Professor and Chair of the Department of Pharmaceutical Sciences at the SU School of Pharmacy in 1995. Dr. Keller has worked for Nature©ˆs Sunshine since 2001.

Speaking at the Natural Health Symposium in Geneva, NY ú December 5, 2003 Sponsored by Robin Helstrom, Christian Natural Health - (315) 781-5114 (The session was video-taped)

Cellular Damage leads to cancer.

(Health Disclaimer) - this information is for educational purposes only.

(Full seminar outline ú but will be abbreviated tonight)

A. Cell Damage

1. Mechanisms 2. Apoptosis (the body disrupting its own metabolic processes, causing cells to be damaged) 3. Repair

B. Consequences of Cell Damage

C. Approaches to protecting cells

1. Lifestyle Assessments 2. Nutritional supplementation

Cell Damage: Mechanisms of Damage

1. Free Radicals - most common: reactive oxygen species; can damage DNA (key to healthy cell replication), this results in a changed genetic code, which can lead to cancer 2. Toxic chemicals ú often referred to as carcinogens (chemicals in cigarettes, certain drugs, alcohol, etc.) 3. Infectious agents ú there are viruses known to cause cancer 4. Immunological and inflammatory 5. Nutritional imbalances 6. Ionizing radiation 7. Physical injury

Apoptosis (self-inflicted cell damage, or programmed cell death, because the cell dies in a very sequential action)

Cell death may be due to:

1. Mechanical or chemical injury (7 previous mechanisms) 2. Cellular suicide (programmed cell death)

Why do cells commit suicide?

A. Normal development - Example (developing baby in the womb) Humans ú finger and toe webbing removed through apoptosis

B. Normal maintenance - Cell sloughing ú uterine lining during menses

C. Destruction of cells that threaten the organism - DNA damage ú cells increase production of p53 (a protein) which is a potent inducer of apoptosis; this is one of the ways the body is able to cope with the existence of cancerous cells (which are forming in your body every day)

Repair of Damage ú whenever a cell is damaged, your body always tries to repair that cell. Sometimes it is impossible, and the cell dies; sometimes it is possible, and the cell returns to a healthy state.

What happens when the cell cannot be repaired, and does not die?

Consequences of Cell Damage:

1. Cancer 2. Asthma 3. Cardiovascular Disease 4. Immune disorders 5. Impaired vision 6. Neurological disorders 7. Osteoarthritis 8. Gastric ulcers

Is cancer inherited?

5-10% are clearly hereditary (genetic); the predisposition to cancer is clearly inherited; if a mother has had breast cancer, her daughter will have a much greater risk factor than normal.

90-95% are involved with genetic mutations caused by chemicals, radiation, hormones, and viruses, changing the chromosomes in the nuclei of our cells. Once a mutation has occurred, and is not repaired, and the cell does not die, then the mutation is passed on as the cell replicates.

Changes in DNA can cause cancer.

Facts and Figures:

* Over 10 million North Americans are battling cancer * One person dies every minute from cancer * WHO calls cancer ©¯an epidemic©˜ * Cancer causes one out of every four deaths in both the US and Canada, and is the second leading cause of death in both countries. * Cancer costs $156 billion a year to treat in the US alone.

Are you at risk?

* 1 man in every 2 will get cancer * 1 woman in 3 will get cancer * 1 woman in 8 will get breast cancer * Genetic predisposition puts some individuals at higher risk.

Cancer Progression:

* Primary tumor ú where the cancer starts * Regional lymph node ú cancer has been spread through the lymphatic fluid, and the cancer will grow there * Distant metastases ú cancer spread from the lymph nodes

Cancer Stages:

* Stage I is early, and most easily treated. * Stage IV is advanced, and very difficult to treat. * ©¯Early diagnosis leads to a better prognosis.©˜

Photos and descriptions of: Lung Cancer Lung cancer metastasized to the liver Oral Cancer Black mole cancer (melanoma ú high concentration of melanin) - characterized by raised, lumpy surface; non-symmetrical; very black; metastasizes very rapidly

Treatments and side effects of cancer treatment: * Surgery (to remove cancerous growth) * Radiation (beam directed at tumor) * Chemotherapy ú chemicals given to combat the cancer ú this is where most side effects occur, due to selective toxicity. The drug acts on normal cells as well as the cancer cells. (bone marrow depression [anemia, infection, hemorrhage]; hair loss (from effect on hair follicle cells, which replicate rapidly); GI bleeding (gastrointestinal tract also lined with cells that replicate rapidly); causes other cancers ú most therapeutic drugs alter the DNA structure and cells of both abnormal and normal cells). (Those who prepare the chemo drugs must wear protective gear to prevent themselves from getting cancer.)

(Paw Paw Info)

Grows east of the Mississippi, native to North America, vs. the Brazilian species Contains Annonaceous Acetogenins * Offer potent anti-tumor and pesticidal activities * Only found in several genera of the Annonacease family. * Over 400 isolated since 1982. * C-35/C-37 fatty acid derivatives * Most heavily concentrated in the twig, in the month of May. So NSP has the twigs wild-crafted during the month of May.

Complexity of Paw Paw

* Over 50 peaks * Isolated one-by-one * Structurally characterized

The perfect example of herbalism ú all act together in concert, to combat cancer.

Four Ways Paw Paw Regulates Damaged Cells (How it combats cancer)

1. Slows and/or stops the production of cellular energy (ATP) in abnormal cells. (Analogy of ATP and gasoline; high quality gasoline in a Porsche will make it run very well; a cell needs ATP to run efficiently and well.) Cancer cells require 17x more energy than a normal cell; this is how cancer cells grow so rapidly. 2. Prevents the growth of vessels in or near the tumor. Cancer cells and tumor growth require a lot of blood, and tumor is usually surrounded by blood vessels (angiogenesis) 3. Depletes the DNA and RNA building blocks necessary for new, abnormal cell division. Nucleotides diminished to prevent new cell division. 4. Kills cells that are resistant to chemotherapy. The cells become resistant because they have developed a pump that pumps the chemo drugs back out of the cells; the drugs have to be able to enter the cell and stay in there. This pump needs energy (ATP) to operate, so by limiting this energy, the cell cannot do that. This is why Paw Paw is so valuable as an adjunct to other traditional chemo treatments.

Paw Paw ú one of the most potent substances known! (Eli Lilly Study) Upjohn Co. showed that Paw Paw compounds are up to 300x more potent than Taxol (done on mice that had leukemia).

Paw Paw is Safe!

* Beagle safety study * Impossible to overdose * 32 (25 mg.) capsules four times a day were non-toxic due to vomiting (twice the dose of what NSP markets) * Conclusion: Paw Paw is more effective than common drugs with no toxicity

NSP was convinced that Paw Paw was not only efficacious, but safe, so NSP started to conduct clinical trials.

* 130 patients over the past 1.5 years (many prostate and breast cancers) * Looked for reduction in tumor size (verified by CT scans, MRIs, etc.) and in tumor antigen levels (PSA, CA2729, CA125, etc.) * Many of these people were in Stage IV of their cancers, beyond help * Very few side effects (only 3 experienced nausea and vomiting; 1 had itching) * No hair loss * No bone marrow depression * No GI bleeding

Testimonials

Breast Cancer ú Patient #12 * Stage IV * 6 weeks of Paw Paw * 50% reduction in tumor markers (160 down to 80) * Size of tumors reduced significantly

Eddie Durmon Testimonial (Neosho, MO) - March, 2003 300 people attended the Regional Meeting (organized by Bonnie Clayton) Eddie had melanoma that had metastasized to his lungs. He could only walk three steps when he started on the Paw Paw. Within 3 days, he started noticing a difference ú he could go 4 steps, and then pretty soon 4-5 steps; and then after months, he could walk out to the barn; and now he is riding a bike and walking long distances.

Products to Avoid

Co-Q10 Stimulates complex I in mitochondria Thyroid stimulators (7-Keto and Thyroid Activator) Stimulate complex I in mitochondria Antioxidants (large doses) - block programmed cell death

Scientific Validation ú several hundred articles written in scientific journals about Paw Paw Terrific article in Journal of Natural Products

Suggested Program ú not intended for prevention

* Paw Paw Cell-Reg * Nature©ˆs Noni * Immune Stimulator * High Potency Protease * Triple Relief ú COX-2 inhibitor; PGE-2 stimulates angiogenesis and interferes with apoptosis; PGE 2 is BAD as far as cancer is concerned, and because Triple Relief contains a COX-2 inhibitor, it will help interfere with metastasis.

Question and Answer

Q: What types of cancer are not treated very well with Paw Paw?

A: Greatest success with breast cancer and prostate Some are not treated well with lymphoma and leukemias ú but the numbers in the clinical study were small so this is not an accurate representation.

Q: How long does a person stay on Paw Paw after their initial cancer diagnosis?

A: Most likely for a long period of time ú throughout the entire time they ©¯have cancer©˜, and then for a period of time after it has been announced to be in remission. Most cancer patients feel better ON the Paw Paw than off, unlike their response to chemo ú they feel better OFF the chemo then ON.

Q: Can Paw Paw be used with children?

A: No pediatric study or clinical trial has been conducted at this point. Trying to get some companies interested in conducting such studies. It is difficult to get people interested ú NSP is trying to promote it but doesn©ˆt want to publicize it TOO much for fear that the FDA will step in and put an end to Paw Paw before the clinical studies have been thoroughly conducted, so it is a tough spot to be in right now.

Q: The toxicity studies were conducted using dogs ú will it be tested on humans?

A: It has been ©¯{tested©˜ in these clinical trials; (one NSP manager did her own trial with Paw Paw and took over 35 pills a day before it made her nauseous; and over 50 pills before it made her vomit). Please bear in mind that in 1898 Paw Paw was marketed as an emetic, and it was not discontinued because it was toxic, but because they replaced it with ipecac.

Q: Can Paw Paw be used for MS?

A: One woman has reported using Paw Paw for MS and has found a distinct improvement and lessening in her MS symptoms. No clinical studies have been done. However, MS is now thought to involve a viral infection, and we know that Paw Paw has anti-viral properties; thus it is effective against AIDS, herpes, etc. There is a new NSP product, Golden Salve with Paw Paw, that really zaps fever blisters.

Q: Will Paw Paw help treat lupus?

A: No, because Paw Paw does not have any effect on auto-immune conditions.

Q: How do you start using Paw Paw, and adjust the dosage?

A: Paw Paw should be taken one capsule, 4x/day ú breakfast, lunch, dinner, and with a healthy bedtime snack. You can start with one pill a day, then go up to two, then three, then four. That is the dosage for an average weight of 150 lbs. You may want to increase the dosage for a heavier person; start low and go slow, and if the person becomes nauseous, back down, and stay at that dosage for a week or so, then start to raise it again, one capsule at a time.

Q: What books do you recommend?

Dr. Barro Tyler©ˆs The Honest Herbal and Herbs of Choice (Dr. Tyler was Dr. Keller©ˆs first herbal mentor when he was studying pharmacology and specializing in pharmacognosy)

Mark Blumenthal©ˆs new book, The Clinical Guide to Herbal Medicine (Mark is the president of the American Botanical Council)

Notes taken and submitted by Sharon Grimes, Homespun Health.